knee osteoarthritis — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5099	Gefapixant	RO 4926219,AF219,MK-7264	P2X Receptor
	Gefapixant (AF219) is a P2X3 receptor (P2X3R) antagonist with IC50 of ~30 nM at recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors.		P2X Receptor
T1109	(Z)-Capsaicin	Zucapsaicin,Civamide,cis-Capsaicin	TRP/TRPV Channel , HSV
	(Z)-Capsaicin (Zucapsaicin) is a medication used to treat osteoarthritis of the knee and Others neuropathic pain.(Z)-Capsaicin is a synthetic cis isomer of natural capsaicin that has shown therapeutic efficacy in pain ac...		TRP/TRPV Channel , HSV
T15358	Funapide	TV 45070,XEN402	Sodium Channel
	Funapide (TV 45070) is a potent Sodium Channel Nav1.7 inhibitor with potential anti-inflammatory activity for the treatment of erythema gangrenosum, musculoskeletal pain, knee osteoarthritis, and postherpetic nerves.		Sodium Channel
T35859	Aldumastat	GLPG1972,S201086,G504572	Others
	Aldumastat (GLPG1972) is a highly potent, specific and orally active inhibitor of ADAMTS-5.Aldumastat is used for the study of osteoarthritis of the knee.		Others
T29663	ADL-5747	ADL-5747 (free base),ADL5747,ADL-5747 free base	Opioid Receptor
	ADL-5747 (ADL-5747 (free base)) (free base) is a delta opioid receptor agonist used in the treatment of neurological disorders, skin and musculoskeletal disorders, and may be used in the study of postherpetic neuralgia, ...		Opioid Receptor
T77092	Nadecnemab	REGN-5069	Others
	Nadecnemab is an IGG4-κantibody targeting GFRA3, a receptor of the glial cell-derived neurotrophic factor family. Nadecnemab can be used for knee osteoarthritis and neurological disorders.		Others
T1641	Strontium ranelate	Distrontium renelate,S12911	Calcium Channel , CaSR
	Strontium ranelate (S12911), a strontium (II) salt of the ranelic acid, is a medication for osteoporosis. Studies indicate it can also slow the course of osteoarthritis of the knee. The drug is unusual in that it both in...		Calcium Channel , CaSR
T30939	Cindunistat HCl maleate	PHA 728669F,SD 6010,PHA-728669F,SD6010 PF-00572986,SD-6010,PHA728669F
	Cindunistat( PHA-728669F, PF-00572986, PHA-84250, SD-6010, and SC-084250) is a potent and oral selective iNOS inhibitor which is expected to be used in patients with symptomatic osteoarthritis of the knee.
T26563	Adavivint HCl (1467093-03-3 free base)	SM-04690,Adavivint HCl,Adavivint,SM04690,SM 04690
	Adavivint, also known as SM04690, is a small-molecule inhibitor of the Wnt pathway which is being investigated as a potential disease modifying agent for the treatment of osteoarthritis of the knee
T78280	Fasinumab
	Fasinumab (Anti-Human NGF), a human IgG1κ monoclonal antibody targeting nerve growth factor (NGF), has applications in clinical studies for acute sciatica and knee osteoarthritis (OA) [1].
T63846	Gefapixant citrate
	Gefapixant citrate is an orally active P2X3 receptor (P2X3R) antagonist that acts on human homologous recombinant hP2X3 (IC50: ~30 nM) and hP2X2/3 (IC50: 100-200 nM). gefapixant citrate can be used to study chronic cough...
T78282	Tanezumab	RN-624,PF 4383119
	Tanezumab (RN-624) is a high-affinity, specific humanized anti-NGF monoclonal antibody (mAb) that inhibits nerve growth factor (NGF) from binding to its p75 and TrkA receptors in the peripheral nervous system. It is util...